BIOGRAPHICAL SKETCH

A. Positions and Honors

Honors

1994      AGA senior research fellowship award

1998      Japanese viral hepatitis research fellowship

2002      Hepatology Research Award (Japanese Society of Hepatology)

2004      Tohoku University Hospital Director Award

2010      Best Research Ajinomoto Award, Japanese Society of Hepatology,

2010      Gold Prize, Tohoku University School of Medicine

2016      Reviewer Award, Japanese Society of Promotion of Science (JSPS)

Positions and Employment

1996-1997           Assistant Professor of Internal Medicine, Tohoku University Graduate School of Medicine

1997-2003           Assistant Professor of Internal Medicine, Tohoku University Hospital

2003-2009           Associate Professor of Internal Medicine, Tohoku University Hospital

2009-2011           Associate Professor of Internal Medicine, Tohoku University Graduate School of Medicine

2011-Current      Professor and Chairman of Gastroenterology, Yamagata University Faculty of Medicine

2020-Current      Dean, Yamagata University Faculty of Medicine

Other Experiences and Professional Memberships

1994    Visiting Professorship, University of Florence ‘Development and characterization of murine model of immune-mediated cholangitis’.

2001      Visiting Professorship, Temple A&M University ‘Fas-mediated cholangiopathy in mouse GVHD model’

2001    Invited Lectureship, the American Association for the Study of Liver Diseases, Basic Research Single Topic Conference ‘The Pathobiology of Biliary Epithelia’, Virginia, USA

AASLD (Fellow)

AGA (Fellow)

European Association for the Study of Liver Disease (EASL)

American College of Physicians (ACP)

American Physiological Society (APS)

APASL (Associate Editor of Hepatology International)  

Japanese Society of Gastroenterology  ( Rormer Editor in Chief, Journal of Gastroenterology)

Japanese Society of Hepatology  

B. Selected peer-reviewed publications (in chronological order)

Original Article           298 peer reviewed original English article.  

Summary:  2 in PNAS, 11 in Gastroenterology, 21 in Hepatology, 3 in J Hepatol, 22 in AJP, as an original paper

SELECTED ARTICLES:

1.    Okamoto H, Ishii M, Mano Y, Igarashi T, Ueno Y, Kobayashi K, et al. Confluent monolayers of bile duct epithelial cells with tight junctions. Hepatology. 1995;22(1):153-9.

2.    Alpini G, Roberts S, Kuntz SM, Ueno Y, Gubba S, Podila PV, et al. Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver. Gastroenterology. 1996;110(5):1636-43.

3.    Ueno Y, Phillips JO, Ludwig J, Lichtman SN, LaRusso NF. Development and characterization of a rodent model of immune-mediated cholangitis. Proceedings of the National Academy of Sciences of the United States of America. 1996;93(1):216-20.

4.    Alpini G, Glaser SS, Ueno Y, Rodgers R, Phinizy JL, Francis H, et al. Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion. Gastroenterology. 1999;116(1):179-86.

5.    Ueno Y, Ishii M, Yahagi K, Mano Y, Kisara N, Nakamura N, et al. Fas-mediated cholangiopathy in the murine model of graft versus host disease. Hepatology. 2000;31(4):966-74.

6.    Alpini G, Ueno Y, Glaser SS, Marzioni M, Phinizy JL, Francis H, et al. Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes. Hepatology. 2001;34(5):868-76.

7.    Lesage G, Glaser S, Ueno Y, Alvaro D, Baiocchi L, Kanno N, et al. Regression of cholangiocyte proliferation after cessation of ANIT feeding is coupled with increased apoptosis. American journal of physiology Gastrointestinal and liver physiology. 2001;281(1):G182-90.

8.    Alpini G, Baiocchi L, Glaser S, Ueno Y, Marzioni M, Francis H, et al. Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. Hepatology. 2002;35(5):1041-52.

9.    Alpini G, Glaser S, Alvaro D, Ueno Y, Marzioni M, Francis H, et al. Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats. Gastroenterology. 2002;123(4):1226-37.

10.  Alpini G, Ueno Y, Tadlock L, Glaser SS, LeSage G, Francis H, et al. Increased susceptibility of cholangiocytes to tumor necrosis factor-alpha cytotoxicity after bile duct ligation. Am J Physiol Cell Physiol. 2003;285(1):C183-94.

11.  Glaser S, Alvaro D, Roskams T, Phinizy JL, Stoica G, Francis H, et al. Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity. American journal of physiology Gastrointestinal and liver physiology. 2003;284(4):G683-94.

12.  Marzioni M, LeSage GD, Glaser S, Patel T, Marienfeld C, Ueno Y, et al. Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct-ligated rats. American journal of physiology Gastrointestinal and liver physiology. 2003;284(5):G837-52.

13.  Francis H, Glaser S, Ueno Y, Lesage G, Marucci L, Benedetti A, et al. cAMP stimulates the secretory and proliferative capacity of the rat intrahepatic biliary epithelium through changes in the PKA/Src/MEK/ERK1/2 pathway. J Hepatol. 2004;41(4):528-37.

14.  Gigliozzi A, Alpini G, Baroni GS, Marucci L, Metalli VD, Glaser SS, et al. Nerve growth factor modulates the proliferative capacity of the intrahepatic biliary epithelium in experimental cholestasis. Gastroenterology. 2004;127(4):1198-209.

15.  LeSage GD, Alvaro D, Glaser S, Francis H, Marucci L, Roskams T, et al. Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP. Hepatology. 2004;40(5):1116-27.

16.  Marienfeld C, Yamagiwa Y, Ueno Y, Chiasson V, Brooks L, Meng F, et al. Translational regulation of XIAP expression and cell survival during hypoxia in human cholangiocarcinoma. Gastroenterology. 2004;127(6):1787-97.

17.  Marzioni M, Glaser S, Francis H, Marucci L, Benedetti A, Alvaro D, et al. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin. Gastroenterology. 2005;128(1):121-37.

18.  Fukushima K, Ueno Y, Inoue J, Kanno N, Shimosegawa T. Filopodia formation via a specific Eph family member and PI3K in immortalized cholangiocytes. American journal of physiology Gastrointestinal and liver physiology. 2006;291(5):G812-9.

19.  Gaudio E, Barbaro B, Alvaro D, Glaser S, Francis H, Franchitto A, et al. Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats. American journal of physiology Gastrointestinal and liver physiology. 2006;291(2):G307-17.

20.  Gaudio E, Barbaro B, Alvaro D, Glaser S, Francis H, Ueno Y, et al. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gastroenterology. 2006;130(4):1270-82.

21.  Glaser S, Alvaro D, Francis H, Ueno Y, Marucci L, Benedetti A, et al. Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt. American journal of physiology Gastrointestinal and liver physiology. 2006;290(4):G813-26.

22.  Mack CL, Tucker RM, Lu BR, Sokol RJ, Fontenot AP, Ueno Y, et al. Cellular and humoral autoimmunity directed at bile duct epithelia in murine biliary atresia. Hepatology. 2006;44(5):1231-9.

23.  Meng F, Yamagiwa Y, Ueno Y, Patel T. Over-expression of interleukin-6 enhances cell survival and transformed cell growth in human malignant cholangiocytes. J Hepatol. 2006;44(6):1055-65.

24.  Wakabayashi K, Lian ZX, Moritoki Y, Lan RY, Tsuneyama K, Chuang YH, et al. IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis. Hepatology. 2006;44(5):1240-9.

25.  Fava G, Ueno Y, Glaser S, Francis H, Demorrow S, Marucci L, et al. Thyroid hormone inhibits biliary growth in bile duct-ligated rats by PLC/IP(3)/Ca(2+)-dependent downregulation of SRC/ERK1/2. Am J Physiol Cell Physiol. 2007;292(4):C1467-75.

26.  Francis H, LeSage G, DeMorrow S, Alvaro D, Ueno Y, Venter J, et al. The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats. Am J Physiol Cell Physiol. 2007;293(4):C1252-62.

27.  Moritoki Y, Lian ZX, Wulff H, Yang GX, Chuang YH, Lan RY, et al. AMA production in primary biliary cirrhosis is promoted by the TLR9 ligand CpG and suppressed by potassium channel blockers. Hepatology. 2007;45(2):314-22.

28.  DeMorrow S, Francis H, Gaudio E, Ueno Y, Venter J, Onori P, et al. Anandamide inhibits cholangiocyte hyperplastic proliferation via activation of thioredoxin 1/redox factor 1 and AP-1 activation. American journal of physiology Gastrointestinal and liver physiology. 2008;294(2):G506-19.

29.  Francis H, Glaser S, Demorrow S, Gaudio E, Ueno Y, Venter J, et al. Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway. Am J Physiol Cell Physiol. 2008;295(2):C499-513.

30.  Glaser S, DeMorrow S, Francis H, Ueno Y, Gaudio E, Vaculin S, et al. Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms. American journal of physiology Gastrointestinal and liver physiology. 2008;295(1):G124-G36.

31.  Kakazu E, Ueno Y, Kondo Y, Fukushima K, Shiina M, Inoue J, et al. Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis. Hepatology. 2009;50(6):1936-45.

32.  Moritoki Y, Lian ZX, Lindor K, Tuscano J, Tsuneyama K, Zhang W, et al. B-cell depletion with anti-CD20 ameliorates autoimmune cholangitis but exacerbates colitis in transforming growth factor-beta receptor II dominant negative mice. Hepatology. 2009;50(6):1893-903.

33.  Moritoki Y, Zhang W, Tsuneyama K, Yoshida K, Wakabayashi K, Yang GX, et al. B cells suppress the inflammatory response in a mouse model of primary biliary cirrhosis. Gastroenterology. 2009;136(3):1037-47.

34.  Glaser S, Lam IP, Franchitto A, Gaudio E, Onori P, Chow BK, et al. Knockout of secretin receptor reduces large cholangiocyte hyperplasia in mice with extrahepatic cholestasis induced by bile duct ligation. Hepatology. 2010;52(1):204-14.

35.  Glaser S, Wang M, Ueno Y, Venter J, Wang K, Chen H, et al. Differential transcriptional characteristics of small and large biliary epithelial cells derived from small and large bile ducts. American journal of physiology Gastrointestinal and liver physiology. 2010;299(3):G769-77.

36.  Obara N, Fukushima K, Ueno Y, Wakui Y, Kimura O, Tamai K, et al. Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice. J Hepatol. 2010;53(2):326-34.

37.  Woo K, Sathe M, Kresge C, Esser V, Ueno Y, Venter J, et al. Adenosine triphosphate release and purinergic (P2) receptor-mediated secretion in small and large mouse cholangiocytes. Hepatology. 2010;52(5):1819-28.

38.  Alpini G, Franchitto A, Demorrow S, Onori P, Gaudio E, Wise C, et al. Activation of alpha(1) -adrenergic receptors stimulate the growth of small mouse cholangiocytes via calcium-dependent activation of nuclear factor of activated T cells 2 and specificity protein 1. Hepatology. 2011;53(2):628-39.

39.  Glaser S, Gaudio E, Renzi A, Mancinelli R, Ueno Y, Venter J, et al. Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice. American journal of physiology Gastrointestinal and liver physiology. 2011;301(2):G297-305.

40.  Renzi A, Glaser S, Demorrow S, Mancinelli R, Meng F, Franchitto A, et al. Melatonin inhibits cholangiocyte hyperplasia in cholestatic rats by interaction with MT1 but not MT2 melatonin receptors. American journal of physiology Gastrointestinal and liver physiology. 2011;301(4):G634-43.

41.  Yang F, Priester S, Onori P, Venter J, Renzi A, Franchitto A, et al. Castration inhibits biliary proliferation induced by bile duct obstruction: novel role for the autocrine trophic effect of testosterone. American journal of physiology Gastrointestinal and liver physiology. 2011;301(6):G981-91.

42.  Yoshida H, Shiratori Y, Kudo M, Shiina S, Mizuta T, Kojiro M, et al. Effect of vitamin K2 on the recurrence of hepatocellular carcinoma. Hepatology. 2011;54(2):532-40.

43.  Frampton G, Ueno Y, Quinn M, McMillin M, Pae HY, Galindo C, et al. The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1. American journal of physiology Gastrointestinal and liver physiology. 2012;303(11):G1202-11.

44.  Meng F, Francis H, Glaser S, Han Y, DeMorrow S, Stokes A, et al. Role of stem cell factor and granulocyte colony-stimulating factor in remodeling during liver regeneration. Hepatology. 2012;55(1):209-21.

45.  Xia X, Jung D, Webb P, Zhang A, Zhang B, Li L, et al. Liver X receptor beta and peroxisome proliferator-activated receptor delta regulate cholesterol transport in murine cholangiocytes. Hepatology. 2012;56(6):2288-96.

46.  Harada K, Hirohara J, Ueno Y, Nakano T, Kakuda Y, Tsubouchi H, et al. Incidence of and risk factors for hepatocellular carcinoma in primary biliary cirrhosis: national data from Japan. Hepatology. 2013;57(5):1942-9.

47.  Mancinelli R, Franchitto A, Glaser S, Meng F, Onori P, Demorrow S, et al. GABA induces the differentiation of small into large cholangiocytes by activation of Ca(2+) /CaMK I-dependent adenylyl cyclase 8. Hepatology. 2013;58(1):251-63.

48.  Renzi A, DeMorrow S, Onori P, Carpino G, Mancinelli R, Meng F, et al. Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes in rats. Hepatology. 2013;57(3):1130-41.

49.  Glaser S, Meng F, Han Y, Onori P, Chow BK, Francis H, et al. Secretin stimulates biliary cell proliferation by regulating expression of microRNA 125b and microRNA let7a in mice. Gastroenterology. 2014;146(7):1795-808 e12.

50.  Graf A, Meng F, Hargrove L, Kennedy L, Han Y, Francis T, et al. Knockout of histidine decarboxylase decreases bile duct ligation-induced biliary hyperplasia via downregulation of the histidine decarboxylase/VEGF axis through PKA-ERK1/2 signaling. American journal of physiology Gastrointestinal and liver physiology. 2014;307(8):G813-23.

51.  Tomita K, Haga H, Mizuno K, Katsumi T, Sato C, Okumoto K, et al. Epiregulin promotes the emergence and proliferation of adult liver progenitor cells. American journal of physiology Gastrointestinal and liver physiology. 2014;307(1):G50-7.

52.  Hatano R, Akiyama K, Tamura A, Hosogi S, Marunaka Y, Caplan MJ, et al. Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice. Hepatology. 2015;61(5):1660-71.

53.  Mizokami M, Yokosuka O, Takehara T, Sakamoto N, Korenaga M, Mochizuki H, et al. Ledipasvir and sofosbuvir fixed-dose combination with and without ribavirin for 12 weeks in treatment-naive and previously treated Japanese patients with genotype 1 hepatitis C: an open-label, randomised, phase 3 trial. Lancet Infect Dis. 2015;15(6):645-53.

54.  Schrumpf E, Tan C, Karlsen TH, Sponheim J, Bjorkstrom NK, Sundnes O, et al. The biliary epithelium presents antigens to and activates natural killer T cells. Hepatology. 2015;62(4):1249-59.

55.  Sasaki Y, Abe Y, Ueno Y. A Rare Cause of Protein-Losing Gastropathy. Gastroenterology. 2016;150(5):1094-5.

56.  Asai Y, Yamada T, Tsukita S, Takahashi K, Maekawa M, Honma M, et al. Activation of the Hypoxia Inducible Factor 1alpha Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones. Gastroenterology. 2017;152(6):1521-35 e8.